Tocris特约代理商|2939-10mg A 83-01 (10 MG)
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公司新闻
Tocris公司试剂|2374-10mg|GW 405833试剂现货促销
发布时间：2017-09-02 18:18 | 点击次数：409
GW 405833
Product Details
Citations (2)
Potent and selective CB2 receptor partial agonist (EC50 = 0.65 nM; maximum inhibition = 44.6%). Binds with high affinity to both human and rat CB2 receptors and displays ~ 1200-fold selectivity over CB1 (Ki values are 3.92 and 4772 nM for human recombinant CB2 and CB1 receptors respectively). Produces potent antihyperalgesic effects in several rodent models of pain.
Technical Data
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M.Wt:447.36
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Formula:C23H24Cl2N2O3
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Solubility:Soluble to 50 mM in DMSO and to 50 mM in ethanol
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Purity:>98%
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Storage:Store at RT
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CAS No:180002-83-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
- CB1 and CB2 cannabinoid receptors are implicated in inflammatory pain.
Clayton et al.
Pain, 2002;96:253 - Pharmacological and pharmacokinetic characterization of the cannabinoid receptor 2 agonist, GW405833, utilizing rodent models of acute and chronic pain, anxiety, ataxia and catalepsy.
Valenzano et al.
Neuropharmacology, 2005;48:658
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